Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults.

ABSTRACT:

Background

Adjunctive glucocorticoids are widely used to treat human immunodeficiency virus (HIV)-associated tuberculous meningitis despite limited data supporting their safety and efficacy.

Methods

We conducted a double-blind, randomized, placebo-controlled trial involving HIV-positive adults (≥18 years of age) with tuberculous meningitis in Vietnam and Indonesia. Participants were randomly assigned to receive a 6-to-8-week tapering course of either dexamethasone or placebo in addition to 12 months of antituberculosis chemotherapy. The primary end point was death from any cause during the 12 months after randomization.

Results

A total of 520 adults were randomly assigned to receive either dexamethasone (263 participants) or placebo (257 participants). The median age

SUBMITTER: Donovan J 

PROVIDER: S-EPMC7615197 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature