Ontology highlight
ABSTRACT:
SUBMITTER: Widmann M
PROVIDER: S-EPMC7615238 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Widmann Melanie M Lieb Andreas A Mutti Anna A Schwarzer Christoph C
Epilepsy research 20230930
In the quest for novel treatments for patients with drug-resistant seizures, poor water solubility of potential drug candidates is a frequent obstacle. Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a confounding influence in epilepsy research, reporting both pro- and antiepileptic effects. In this study, we aim to clarify the effects of DMSO on epileptiform activity in one of the most frequently studied models of chronic epilepsy, the intrahippocampal ...[more]