Bundle myelin fraction (BMF) mapping of different white matter connections using microstructure informed tractography.

ABSTRACT: To date, we have scarce information about the relative myelination level of different fiber bundles in the human brain. Indirect evidence comes from postmortem histology data but histological stainings are unable to follow a specific bundle and determine its intrinsic myelination. In this context, quantitative MRI, and diffusion MRI tractography may offer a viable solution by providing, respectively, voxel-wise myelin sensitive maps and the pathways of the major tracts of the brain. Then, "tractometry" can be used to combine these two pieces of information by averaging tissue features (obtained from any voxel-wise map) along the streamlines recovered with diffusion tractography. Although this method has been widely used in the literature, in cases of voxels containing multiple fiber popula

SUBMITTER: Schiavi S 

PROVIDER: S-EPMC7615247 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature