Single-cell transcriptomic characterization of a gastrulating human embryo.

ABSTRACT: Gastrulation is the fundamental process in all multicellular animals through which the basic body plan is first laid down^1-4. It is pivotal in generating cellular diversity coordinated with spatial patterning. In humans, gastrulation occurs in the third week after fertilization. Our understanding of this process in humans is relatively limited and based primarily on historical specimens^5-8, experimental models^9-12 or, more recently, in vitro cultured samples^13-16. Here we characterize in a spatially resolved manner the single-cell transcriptional profile of an entire gastrulating human embryo, staged to be between 16 and 19 days after fertilization. We use these data to analyse the cell types present and to make comparisons with other model syste

SUBMITTER: Tyser RCV 

PROVIDER: S-EPMC7615353 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature