Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.

ABSTRACT: Background: Increased height has been associated with increased risk of hypothyroidism or thyroid cancer in epidemiological studies. However, the potential causal association between height and hypothyroidism or thyroid cancer has not been thoroughly explored. Autoimmune thyroid disease (AITD) mainly presents as hypothyroidism, thus we aim to evaluate the causal relationship between height as exposure and its association with AITD or thyroid cancer. Methods: Mendelian randomization (MR) analyses were performed by using genetic instruments associated with height, which were selected from the largest genome-wide association meta-analysis for height in up to 5.4 million individuals. Summary-level data for AITD and thyroid cancer (including 30,234 and 3001 cases, re

SUBMITTER: Papadopoulou A 

PROVIDER: S-EPMC7615364 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature