The extracellular matrix dictates regional competence for tumour initiation.

ABSTRACT: The skin epidermis is constantly renewed throughout life^1,2. Disruption of the balance between renewal and differentiation can lead to uncontrolled growth and tumour initiation³. However, the ways in which oncogenic mutations affect the balance between renewal and differentiation and lead to clonal expansion, cell competition, tissue colonization and tumour development are unknown. Here, through multidisciplinary approaches that combine in vivo clonal analysis using intravital microscopy, single-cell analysis and functional analysis, we show how SmoM2-a constitutively active oncogenic mutant version of Smoothened (SMO) that induces the development of basal cell carcinoma-affects clonal competition and tumour initiation in real time. We found that expressing SmoM2 in t

SUBMITTER: Bansaccal N 

PROVIDER: S-EPMC7615367 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature