Effect of Propofol on Heart Rate and Its Coupling to Cortical Slow Waves in Humans.

ABSTRACT:

Background

Propofol causes significant cardiovascular depression and a slowing of neurophysiological activity. However, literature on its effect on the heart rate remains mixed, and it is not known whether cortical slow waves are related to cardiac activity in propofol anesthesia.

Methods

The authors performed a secondary analysis of electrocardiographic and electroencephalographic data collected as part of a previously published study where n = 16 healthy volunteers underwent a slow infusion of propofol up to an estimated effect-site concentration of 4 µg/ml. Heart rate, heart rate variability, and individual slow electroencephalographic waves were extracted for each subject. Timing between slow-wave start and the preceding R-wave was tested against a uniform random surroga

SUBMITTER: Fabus MS 

PROVIDER: S-EPMC7615371 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature