Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T_reg depletion.

ABSTRACT: Regulatory T (T_reg) cells contribute to immune homeostasis but suppress immune responses to cancer. Strategies to disrupt T_reg cell-mediated cancer immunosuppression have been met with limited clinical success, but the underlying mechanisms for treatment failure are poorly understood. By modeling T_reg cell-targeted immunotherapy in mice, we find that CD4⁺ Foxp3^- conventional T (T_conv) cells acquire suppressive function upon depletion of Foxp3⁺ T_reg cells, limiting therapeutic efficacy. Foxp3^- T_conv cells within tumors adopt a T_reg cell-like transcriptional profile upon ablation of T_reg cells and acquire the ability to suppress T cell activation and proliferati

SUBMITTER: Whiteside SK 

PROVIDER: S-EPMC7615475 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature