Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses.

ABSTRACT:

Background

Inflammation is associated with depression, but causality remains unclear. We investigated potential causality and direction of effect between inflammation and depression.

Methods

Using data from the ALSPAC birth cohort (n = 4021; 42.18 % male), we used multivariable regression to investigate bidirectional longitudinal associations of GlycA and depression and depression symptoms, assessed at ages 18y and 24y. We used two-sample Mendelian randomization (MR) to investigate potential causality and directionality. Genetic variants for GlycA were obtained from UK Biobank (UKB) (N = 115,078); for depression from the Psychiatric Genomics Consortium and UKB (N = 500,199); and for depressive symptoms (N = 161,460) from the Social Science Genetic Association Consortium. In

SUBMITTER: Crick DCP 

PROVIDER: S-EPMC7615476 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature