Selection of genetic instruments in Mendelian randomisation studies of sleep traits.

ABSTRACT: This review explores the criteria used for the selection of genetic instruments of sleep traits in the context of Mendelian randomisation studies. This work was motivated by the fact that instrument selection is the most important decision when designing a Mendelian randomisation study. As far as we are aware, no review has sought to address this to date, even though the number of these studies is growing rapidly. The review is divided into the following sections which are essential for genetic instrument selection: 1) Single-gene region vs polygenic analysis; 2) Polygenic analysis: biologically-vs statistically-driven approaches; 3) P-value; 4) Linkage disequilibrium clumping; 5) Sample overlap; 6) Type of exposure; 7) Total (R²) and average strength (F-statistic) metrics; 8) N

SUBMITTER: Paz V 

PROVIDER: S-EPMC7615498 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature