Ontology highlight
ABSTRACT:
SUBMITTER: Man S
PROVIDER: S-EPMC7615501 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Man Stephen S Redman James E JE Cross Deborah L DL Cole David K DK Can Ilona I Davies Bethan B Hashimdeen Shaikh Shimaz SS Reid Reiss R Llewellyn-Lacey Sian S Miners Kelly L KL Ladell Kristin K Lissina Anya A Brown Paul E PE Wooldridge Linda L Price David A DA Rizkallah Pierre J PJ
Journal of immunology (Baltimore, Md. : 1950) 20210728 4
The human CD8<sup>+</sup> T cell clone 6C5 has previously been shown to recognize the <i>tert</i>-butyl-modified Bax<sub>161-170</sub> peptide LLSY(3-<i>t</i>Bu)FGTPT presented by HLA-A*02:01. This nonnatural epitope was likely created as a by-product of fluorenylmethoxycarbonyl protecting group peptide synthesis and bound poorly to HLA-A*02:01. In this study, we used a systematic approach to identify and characterize natural ligands for the 6C5 TCR. Functional analyses revealed that 6C5 T cells ...[more]