Rapid-acting antidepressant drugs modulate affective bias in rats.

ABSTRACT: How rapid-acting antidepressants (RAADs), such as ketamine, induce immediate and sustained improvements in mood in patients with major depressive disorder (MDD) is poorly understood. A core feature of MDD is the prevalence of cognitive processing biases associated with negative affective states, and the alleviation of negative affective biases may be an index of response to drug treatment. Here, we used an affective bias behavioral test in rats, based on an associative learning task, to investigate the effects of RAADs. To generate an affective bias, animals learned to associate two different digging substrates with a food reward in the presence or absence of an affective state manipulation. A choice between the two reward-associated digging substrates was used to quantify the affective bi

SUBMITTER: Hinchcliffe JK 

PROVIDER: S-EPMC7615567 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature