In vivo evidence of microstructural hypo-connectivity of brain white matter in 22q11.2 deletion syndrome.

ABSTRACT: 22q11.2 deletion syndrome, or 22q11.2DS, is a genetic syndrome associated with high rates of schizophrenia and autism spectrum disorders, in addition to widespread structural and functional abnormalities throughout the brain. Experimental animal models have identified neuronal connectivity deficits, e.g., decreased axonal length and complexity of axonal branching, as a primary mechanism underlying atypical brain development in 22q11.2DS. However, it is still unclear whether deficits in axonal morphology can also be observed in people with 22q11.2DS. Here, we provide an unparalleled in vivo characterization of white matter microstructure in participants with 22q11.2DS (12-15 years) and those undergoing typical development (8-18 years) using a customized magnetic resonance imaging scanner wh

SUBMITTER: Raven EP 

PROVIDER: S-EPMC7615578 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature