Genetically predicted plasma cortisol and common chronic diseases: A Mendelian randomization study.

ABSTRACT:

Objective

Cushing's syndrome is characterized by hypercortisolaemia and is frequently accompanied by comorbidities such as type 2 diabetes, hypertension, osteoporosis, depression and schizophrenia. It is unclear whether moderate but lifelong hypercortisolaemia is causally associated with these diseases in the general population. We aimed to address this research gap using a Mendelian randomization approach.

Methods

We used three cortisol-associated genetic variants in the SERPINA6/SERPINA1 region as genetic instruments in a two-sample, inverse-variance-weighted Mendelian randomization analysis. We obtained summary-level statistics for cortisol and disease outcomes from publicly available genetic consortia, and meta-analysed them as appropriate. We conducted a multivariable M

SUBMITTER: Lee WH 

PROVIDER: S-EPMC7615603 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature