Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.

ABSTRACT: Existing neurostimulation systems implanted for the treatment of neurodegenerative disorders generally deliver invariable therapy parameters, regardless of phase of the sleep/wake cycle. However, there is considerable evidence that brain activity in these conditions varies according to this cycle, with discrete patterns of dysfunction linked to loss of circadian rhythmicity, worse clinical outcomes and impaired patient quality of life. We present a targeted concept of circadian neuromodulation using a novel device platform. This system utilises stimulation of circuits important in sleep and wake regulation, delivering bioelectronic cues (Zeitgebers) aimed at entraining rhythms to more physiological patterns in a personalised and fully configurable manner. Preliminary evidence from its firs

SUBMITTER: Deli A 

PROVIDER: S-EPMC7615625 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature