Group A <i>Streptococcus</i> induces CD1a-autoreactive T cells and promotes psoriatic inflammation.

ABSTRACT: Group A Streptococcus (GAS) infection is associated with multiple clinical sequelae, including different subtypes of psoriasis. Such post-streptococcal disorders have been long known but are largely unexplained. CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied. Here, we investigated whether GAS-responsive CD1a-restricted T cells contribute to the pathogenesis of psoriasis. Healthy individuals had high frequencies of circulating and cutaneous GAS-responsive CD4⁺ and CD8⁺ T cells with rapid effector functions, including the production of interleukin-22 (IL-22). Human skin and blood single-cell CITE-seq analyses of IL-22-producing T cells sh

SUBMITTER: Chen YL 

PROVIDER: S-EPMC7615662 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature