Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities.

ABSTRACT:

Background

Venous thromboembolism (VTE) has been associated with several modifiable factors (MFs) and cardiovascular comorbidities. However, the mechanisms are largely unknown.

Objectives

We aimed to decipher proteomic pathways underlying the associations of VTE with MFs and cardiovascular comorbidities.

Methods

A 2-stage network Mendelian randomization analysis was conducted to explore the associations between 15 MFs, 1151 blood proteins, and VTE using data from a genome-wide meta-analysis including 81 190 cases of VTE. We used protein data from 35 559 individuals as the discovery analysis, and from 2 independent studies including 10 708 and 54 219 participants as the replication analyses. Based on the identified proteins, we assessed the druggability and examined th

SUBMITTER: Yuan S 

PROVIDER: S-EPMC7615672 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature