DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc₁.

ABSTRACT: New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new chemical entities that are suitable for clinical development for the treatment of Leishmania remains low. Here, we describe the discovery and preclinical development of DNDI-6174, an inhibitor of Leishmania cytochrome bc₁ complex activity that originated from a phenotypically identified pyrrolopyrimidine series. This compound fulfills all target candidate profile criteria required for progression into preclinical development. In addition to good metabolic stability and pharmacokinetic properties, DNDI-6174 demonstrates potent in vitro activity against a variety of Leishmania spe

SUBMITTER: Braillard S 

PROVIDER: S-EPMC7615677 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature