Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

ABSTRACT: Chikungunya virus (CHIKV) is a mosquito-transmitted virus of special concern as it causes Chikungunya fever, characterized by an acute febrile illness, rash, and arthralgia that can progress to chronic and debilitating arthritic symptoms. The effects of climate change on the geographic distribution of the mosquito vector has the potential to expose more of the globe to this virus. No antiviral agents or vaccines are currently available against CHIKV infection and the development of novel therapies that may lead to a future treatment is therefore necessary. In this context, the ADP-ribose binding site of the CHIKV nsP3 macro domain has been reported as a potential target for the development of antivirals. Mutations in the ADP-ribose binding site demonstrated decreased viral replication in c

SUBMITTER: Shimizu JF 

PROVIDER: S-EPMC7615700 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature