Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic.

ABSTRACT: Thuricin CD is a two-peptide antimicrobial produced by Bacillus thuringiensis. Unlike previous antibiotics, it has shown narrow spectrum activity against Clostridioides difficile, a bacterium capable of causing infectious disease in the colon. However, peptide antibiotics have stability, solubility, and permeability problems that can affect their performance in vivo. This work focuses on the bioactivity and bioavailability of thuricin CD with a view to developing a formulation for delivery of active thuricin CD peptides through the gastrointestinal tract (GIT) for local delivery in the colon. The results indicate that thuricin CD is active at low concentrations only when both peptides are present. While thuricin CD was degraded by proteases and was unstable and poorly soluble in gastric fl

SUBMITTER: Viera Herrera C 

PROVIDER: S-EPMC7615751 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature