Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen.

ABSTRACT:

Background

The cyclooxygenase inhibitor ibuprofen may be used to treat patent ductus arteriosus (PDA) in preterm infants. Whether selective early treatment of large PDAs with ibuprofen would improve short-term outcomes is not known.

Methods

We conducted a multicenter, randomized, double-blind, placebo-controlled trial evaluating early treatment (≤72 hours after birth) with ibuprofen for a large PDA (diameter of ≥1.5 mm with pulsatile flow) in extremely preterm infants (born between 23 weeks 0 days' and 28 weeks 6 days' gestation). The primary outcome was a composite of death or moderate or severe bronchopulmonary dysplasia evaluated at 36 weeks of postmenstrual age.

Results

A total of 326 infants were assigned to receive ibuprofen and 327 to receive placebo; 324 and 3

SUBMITTER: Gupta S 

PROVIDER: S-EPMC7615774 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature