Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson's disease.

ABSTRACT:

Background

Gait impairment has a major impact on quality of life in patients with Parkinson's disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15-30 Hz) may contribute to gait impairment, but the precise dynamics of this oscillatory activity during gait remain unclear. Additionally, auditory cues are known to lead to improvements in gait kinematics in PD. If the neurophysiological mechanisms of this cueing effect were better understood they could be leveraged to treat gait impairments using adaptive Deep Brain Stimulation (aDBS) technologies.

Objective

We aimed to characterize the dynamics of subthalamic nucleus (STN) oscillatory activity during stepping movements in PD and to establish the neurophysiological mechanisms by which auditory

SUBMITTER: Yeh CH 

PROVIDER: S-EPMC7616027 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature