Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.

ABSTRACT: Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence, when sleep disruption by delayed chronotypes and societal pressures coincides with our brains preparing for adult life via intense refinement of neural connectivity. These vulnerabilities converge on the prefrontal cortex, one of the last brain regions to mature and a central hub of the limbic-cortical circuits underpinning decision-making, reward processing, social interactions and emotion. Even subtle disruption of prefrontal cortical development during adolescence may therefore have enduring impact. In this review, we integrate synaptic and circuit mechanisms, glial biology, sleep neurophysiology and epidemiolo

SUBMITTER: Anastasiades PG 

PROVIDER: S-EPMC7616212 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature