Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.

ABSTRACT:

Background

Congenital heart disease (CHD) is common and is associated with impaired early brain development and neurodevelopmental outcomes, yet the exact mechanisms underlying these associations are unclear.

Purpose

To utilize MRI data from a cohort of fetuses with CHD as well as typically developing fetuses to test the hypothesis that expected cerebral substrate delivery is associated with total and regional fetal brain volumes.

Study type

Retrospective case-control study.

Population

Three hundred eighty fetuses (188 male), comprising 45 healthy controls and 335 with isolated CHD, scanned between 29 and 37 weeks gestation. Fetuses with CHD were assigned into one of four groups based on expected cerebral substrate delivery.

Field strength/sequence

T2-we

SUBMITTER: Cromb D 

PROVIDER: S-EPMC7616254 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature