A pilot study on the differential urine proteomic profile of subjects with community-acquired acute kidney injury who recover versus those who do not recover completely at 4 months after hospital discharge.

ABSTRACT:

Background

Community-acquired acute kidney injury (CA-AKI) is a sudden structural damage and loss of kidney function in otherwise healthy individuals outside of hospital settings having high morbidity and mortality rates worldwide. Long-term sequelae of AKI involve an associated risk of progression to chronic kidney disease (CKD). Serum creatinine (SCr), the currently used clinical parameter for diagnosing AKI, varies greatly with age, gender, diet, and muscle mass. In the present study, we investigated the difference in urinary proteomic profile of subjects that recovered (R) and incompletely recovered (IR) from CA-AKI, 4 months after hospital discharge.

Methods

Study subjects were recruited from ongoing study of CA-AKI cohort. Patients with either sex or age > 18 years wit

SUBMITTER: Kaur H 

PROVIDER: S-EPMC7616407 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature