Recruited atypical Ly6G⁺ macrophages license alveolar regeneration after lung injury.

ABSTRACT: The lung is constantly exposed to airborne pathogens and particles that can cause alveolar damage. Hence, appropriate repair responses are essential for gas exchange and life. Here, we deciphered the spatiotemporal trajectory and function of an atypical population of macrophages after lung injury. Post-influenza A virus (IAV) infection, short-lived monocyte-derived Ly6G-expressing macrophages (Ly6G⁺ Macs) were recruited to the alveoli of lung perilesional areas. Ly6G⁺ Macs engulfed immune cells, exhibited a high metabolic potential, and clustered with alveolar type 2 epithelial cells (AT2s) in zones of active epithelial regeneration. Ly6G⁺ Macs were partially dependent on granulocyte-macrophage colony-stimulating factor and interleukin-4 receptor signaling

SUBMITTER: Ruscitti C 

PROVIDER: S-EPMC7616420 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature