Broad-spectrum antibiotics disrupt homeostatic efferocytosis.

ABSTRACT: The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasis and prevention of autoimmunity¹. Although past studies have elucidated local molecular signals that regulate homeostatic efferocytosis in a tissue^2,3, whether signals arising distally also regulate homeostatic efferocytosis remains elusive. Here, we show that large peritoneal macrophage (LPM) display impairs efferocytosis in broad-spectrum antibiotics (ABX)-treated, vancomycin-treated and germ-free mice in vivo, all of which have a depleted gut microbiota. Mechanistically, the microbiota-derived short-chain fatty acid butyrate directly boosts efferocytosis efficiency and capacity in mouse and human macrophages, and rescues ABX-induced LPM efferocytosis defects in vivo. Bulk mes

SUBMITTER: Saavedra PHV 

PROVIDER: S-EPMC7616532 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature