Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization.

ABSTRACT:

Objective

PMR is an age-related inflammatory disease of unknown cause. We aimed to identify potentially modifiable risk factors and therapeutic targets for preventing or treating PMR.

Methods

We meta-analysed genetic association data from 8156 cases of PMR (defined using diagnostic codes and self-report) and 416 495 controls of European ancestry from the UK Biobank and FinnGen. We then performed Mendelian randomization analyses to estimate the association between eight modifiable risk factors (using data from up to 1.2 million individuals) and 65 inflammation-related circulating proteins (up to 55 792 individuals), using the inverse variance weighted and pleiotropy robust methods.

Results

We identified three novel genome-wide significant loci in the IL1R1, NEK6 and CC

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC7616751 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature