Estimating Time-Varying Exposure Effects Through Continuous-Time Modelling in Mendelian Randomization.

ABSTRACT: Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the time-varying causal effect of the exposure can yield detailed insights into mechanistic effects and the potential impact of public health interventions. Recently, a growing number of Mendelian randomization studies have attempted to explore time-varying causal effects. However, the proposed approaches oversimplify temporal information and rely on overly restrictive structural assumptions, limiting their reliability in addressing time-varying causal problems. This article considers a novel approach to estimate time-varying effects through continuous-time modelling

SUBMITTER: Tian H 

PROVIDER: S-EPMC7616825 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature