In Vitro and Preclinical Systematic Dose-Effect Studies of Auger Electron- and β Particle-Emitting Radionuclides and External Beam Radiation for Cancer Treatment.

ABSTRACT:

Purpose

Despite a rise in clinical use of radiopharmaceutical therapies, the biological effects of radionuclides and their relationship with absorbed radiation dose are poorly understood. Here, we set out to define this relationship for Auger electron emitters [^99mTc]TcO₄^- and [¹²³I]I^- and β^--particle emitter [¹⁸⁸Re]ReO₄^-. Studies were carried out using genetically modified cells that permitted direct radionuclide comparisons.

Methods and materials

Triple-negative MDA-MB-231 breast cancer cells expressing the human sodium iodide symporter (hNIS) and green fluorescent protein (GFP; MDA-MB-231.hNIS-GFP) were used. In vitro radiotoxicity of [^99mTc]TcO_4</

SUBMITTER: Costa IM 

PROVIDER: S-EPMC7616868 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature