Mapping associations of polygenic scores with autistic and ADHD traits in a single city region.

ABSTRACT:

Background

The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?

Methods

We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.

Results

Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable

SUBMITTER: Reed ZE 

PROVIDER: S-EPMC7616875 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature