Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease.

ABSTRACT:

Background

The gastrointestinal microbiota has an important role in mucosal immune homoeostasis and may contribute to maintaining mucosal healing in Crohn's disease (CD).

Aim

To identify changes in the microbiota, metabolome and protease activity associated with mucosal healing in established paediatric CD METHODS: Twenty-five participants aged 3-18 years with CD, disease duration of over 6 months, and maintenance treatment with biological therapy were recruited. They were divided into a low calprotectin group (faecal calprotectin <100 μg/g, "mucosal healing," n = 11), and a high calprotectin group (faecal calprotectin >100 μg/g, "mucosal inflammation," n = 11). 16S gene-based metataxonomics, ¹ H-NMR spectroscopy-based metabolic profiling and protease activity ass

SUBMITTER: Taylor H 

PROVIDER: S-EPMC7616911 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature