Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy.

ABSTRACT: The poor delivery of nanoparticles to target cancer cells hinders their success in the clinical setting. In this work, an alternative target readily available for circulating nanoparticles has been selected to eliminate the need for nanoparticle penetration in the tissue: the tumor blood vessels. A tumor endothelium-targeted nanoparticle (employing an RGD-containing peptide) capable of co-delivering two anti-vascular drugs (one anti-angiogenic drug and one vascular disruption agent) is here presented. Furthermore, the nanodevice presents two additional anti-vascular capabilities upon activation by Near-Infrared light: provoking local hyperthermia (by gold nanorods in the system) and generating toxic reactive oxygen species (by the presence of a photosensitizer). RGD-targeting is shown to i

SUBMITTER: Paris JL 

PROVIDER: S-EPMC7616912 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature