MRI heterogeneity analysis for prediction of recurrence and disease free survival in anal cancer.

ABSTRACT:

Background

The aim of this study was to evaluate the role of image heterogeneity analysis of standard care magnetic resonance imaging (MRI) in patients with anal squamous cell carcinoma (ASCC) to predict chemoradiotherapy (CRT) outcome. The ability to predict disease recurrence following CRT has the potential to inform personalized radiotherapy approaches currently being explored in novel clinical trials.

Methods

An IRB waiver was obtained for retrospective analysis of standard care MRIs from ASCC patients presenting between 2010 and 2014. Whole tumor 3D volume-of-interest (VOI) was outlined on T2-weighted (T2w) and diffusion weighted imaging (DWI) of the pre- and post-treatment scans. Independent imaging features most predictive of disease recurrence were added to the basel

SUBMITTER: Owczarczyk K 

PROVIDER: S-EPMC7617040 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature