The Neural Engine: A Reprogrammable Low Power Platform for Closed-Loop Optogenetics.

ABSTRACT: Brain-machine Interfaces (BMI) hold great potential for treating neurological disorders such as epilepsy. Technological progress is allowing for a shift from open-loop, pacemaker-class, intervention towards fully closed-loop neural control systems. Low power programmable processing systems are therefore required which can operate within the thermal window of 2° C for medical implants and maintain long battery life. In this work, we have developed a low power neural engine with an optimized set of algorithms which can operate under a power cycling domain. We have integrated our system with a custom-designed brain implant chip and demonstrated the operational applicability to the closed-loop modulating neural activities in in-vitro and in-vivo brain tissues: the local field potentials can be

SUBMITTER: Luo J 

PROVIDER: S-EPMC7617047 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature