Fiber reinforced hydrated networks recapitulate the poroelastic mechanics of articular cartilage.

ABSTRACT: The role of poroelasticity on the functional performance of articular cartilage has been established in the scientific literature since the 1960s. Despite the extensive knowledge on this topic there remain few attempts to design for poroelasticity and to our knowledge no demonstration of an engineered poroelastic material that approaches the physiological performance. In this paper, we report on the development of an engineered material that begins to approach physiological poroelasticity. We quantify poroelasticity using the fluid load fraction, apply mixture theory to model the material system, and determine cytocompatibility using primary human mesenchymal stem cells. The design approach is based on a fiber reinforced hydrated network and uses routine fabrication methods (electrohydrody

SUBMITTER: Moore AC 

PROVIDER: S-EPMC7617126 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature