Electron attachment to fluorodeoxyglucose: Dissociation dynamics in a molecule of near-zero electron affinity.

ABSTRACT: Fluorodeoxyglucose (FDG) is a glucose derivative with fluorine at the C₂ position. The molecule containing the radioactive F-18 isotope is well known from its application in positron emission tomography as a radiotracer in tumor examination. In the stable form with the F-19 isotope, FDG was proposed as a potential radiosensitizer. Since reduction processes may be relevant in radiosensitization, we investigated low-energy electron attachment to FDG with a crossed electron-molecule beam experiment and with quantum chemical calculations as well as molecular dynamics at elevated temperatures to reveal statistical dissociation. We experimentally find that the susceptibility of FDG to low-energy electrons is relatively low. The calculations indicate that upon attachment of an electron

SUBMITTER: Arthur-Baidoo E 

PROVIDER: S-EPMC7617131 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature