A Systematic Online Living Evidence Summary of experimental Alzheimer's disease research.

ABSTRACT:

Background

Despite extensive investment, the development of effective treatments for Alzheimer's disease (AD) has been largely unsuccessful. To improve translation, it is crucial to ensure the quality and reproducibility of foundational evidence generated from laboratory models. Systematic reviews play a key role in providing an unbiased overview of the evidence, assessing rigour and reporting, and identifying factors that influence reproducibility. However, the sheer pace of evidence generation is prohibitive to evidence synthesis and assessment.

New method

To address these challenges, we have developed AD-SOLES, an integrated workflow of automated tools that collect, curate, and visualise the totality of evidence from in vivo experiments.

Results

AD-SOLES is a publi

SUBMITTER: Hair K 

PROVIDER: S-EPMC7617163 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature