Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease.

ABSTRACT:

Aims

The molecular mechanisms underlying the association between type 2 diabetes (T2D) and gastrointestinal (GI) disease are unclear. To identify protein pathways, we conducted a two-stage network Mendelian randomisation (MR) study.

Materials and methods

Genetic instruments for T2D were obtained from a large-scale summary-level genome-wide meta-analysis. Genetic associations with blood protein levels were obtained from three genome-wide association studies on plasma proteins (i.e. the deCODE study as the discovery and the UKB-PPP and Fenland studies as the replication). Summary-level data on 10 GI diseases were derived from genome-wide meta-analysis of the UK Biobank and FinnGen. MR and colocalisation analyses were performed. Pathways were constructed according to the direct

SUBMITTER: Geng J 

PROVIDER: S-EPMC7617254 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature