Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients.

ABSTRACT:

Objective

Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.

Design

Longitudinal observational study.

Setting

Memory clinic, Karolinska University Hospital, Stockholm, Sweden.

Participants

Consecutive patients (n = 162) who agreed to take part in the Cortisol and Stress in AD (Co-STAR) study during 2014-2017 and had data available for variables of interest.

Measurements

Participants rated their depressive symptoms using the Geriatric Depression Scale (GDS) and collected diurnal salivary cortisol samples at home. Cognitive performance was assessed by standardized cognitive tests in the following domains: mem

SUBMITTER: Adedeji DO 

PROVIDER: S-EPMC7617257 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature