Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration.

ABSTRACT: Neuroinflammation is an important pathogenic mechanism in many neurodegenerative diseases, including those caused by frontotemporal lobar degeneration. Post-mortem and in vivo imaging studies have shown brain inflammation early in these conditions, proportional to symptom severity and rate of progression. However, evidence for corresponding blood markers of inflammation and their relationships to central inflammation and clinical outcome are limited. There is a pressing need for such scalable, accessible and mechanistically relevant blood markers because these will reduce the time, risk and costs of experimental medicine trials. We therefore assessed inflammatory patterns of serum cytokines from 214 patients with clinical syndromes associated with frontotemporal lobar degeneration in compa

SUBMITTER: Malpetti M 

PROVIDER: S-EPMC7617268 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature