Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in mice.

ABSTRACT: As a widespread global issue, protein deficiency hinders development and optimal growth in offspring. Maternal low-protein diet influences the development of age-related diseases, including sarcopenia, by altering the epigenome and organ structure through potential increase in oxidative stress. However, the long-term effects of lactational protein restriction or postnatal lifelong protein restriction on the neuromuscular system have yet to be elucidated. Our results demonstrated that feeding a normal protein diet after lactational protein restriction did not have significant impacts on the neuromuscular system in later life. In contrast, a lifelong low-protein diet induced a denervation phenotype and led to demyelination in the sciatic nerve, along with an increase in the number of central

SUBMITTER: Ersoy U 

PROVIDER: S-EPMC7617303 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature