Spontaneous Brain Activity Emerges from Pairwise Interactions in the Larval Zebrafish Brain.

ABSTRACT: Brain activity is characterized by brainwide spatiotemporal patterns that emerge from synapse-mediated interactions between individual neurons. Calcium imaging provides access to in vivo recordings of whole-brain activity at single-neuron resolution and, therefore, allows the study of how large-scale brain dynamics emerge from local activity. In this study, we use a statistical mechanics approach-the pairwise maximum entropy model-to infer microscopic network features from collective patterns of activity in the larval zebrafish brain and relate these features to the emergence of observed whole-brain dynamics. Our findings indicate that the pairwise interactions between neural populations and their intrinsic activity states are sufficient to explain observed whole-brain dynamics. In

SUBMITTER: Rosch RE 

PROVIDER: S-EPMC7617382 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature