CCN4 (WISP-1) reduces apoptosis and atherosclerotic plaque burden in an ApoE mouse model.

ABSTRACT:

Background and aims

CCN4/WISP-1 regulates various cell behaviours that contribute to atherosclerosis progression, including cell adhesion, migration, proliferation and survival. We therefore hypothesised that CCN4 regulates the development and progression of atherosclerotic plaques.

Methods

We used a high fat fed ApoE^-/- mouse model to study atherosclerotic plaque progression in the brachiocephalic artery and aortic root. In protocol 1, male ApoE^-/- mice with established plaques were given a CCN4 helper-dependent adenovirus to see the effect of treatment with CCN4, while in protocol 2 male CCN4^-/-ApoE^-/- were compared to CCN4^+/+ApoE^-/- mice to assess the effect of CCN4 deletion on plaque progression.

Result

SUBMITTER: Williams H 

PROVIDER: S-EPMC7617386 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature