Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review.

ABSTRACT:

Introduction

Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes.

Areas covered

This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or prognosis of DILI. Following a comprehensive search, we included all types of studies in humans. We included DILI cases based on any threshold criteria but excluded intrinsic DILI, commonly caused by paracetamol overdose. We classified studies into diagnostic and prognostic categories and assessed their methodological quality. After reviewing the literature, 14 studies were eligible.

Expert opinion

Diagnostic studies were hete

SUBMITTER: Atallah E 

PROVIDER: S-EPMC7617394 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature