GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration.

ABSTRACT:

Introduction

We examined how abnormal prefrontal neurophysiology and changes in gamma-aminobutyric acid-ergic (GABAergic) neurotransmission contribute to behavioral impairments in disorders associated with frontotemporal lobar degeneration (FTLD).

Methods

We recorded magnetoencephalography during an adaptive visuomotor task from 11 people with behavioral-variant frontotemporal dementia, 11 with progressive supranuclear palsy, and 20 age-matched controls. We used tiagabine, a gamma-aminobutyric acid (GABA) re-uptake inhibitor, as a pharmacological probe to assess the role of GABA during motor-related beta power changes.

Results

Task impairments were associated with diminished movement-related beta power. Tiagabine facilitated partial recovery of behavioral impairments

SUBMITTER: Hughes LE 

PROVIDER: S-EPMC7617437 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature