Subthalamic γ Oscillation Underlying Rapid Eye Movement Sleep Abnormality in Parkinsonian Patients.

ABSTRACT:

Background

Abnormal rapid eye movement (REM) sleep, including REM sleep behavior disorder (RBD) and reduced REM sleep, is common in Parkinson's disease (PD), highlighting the importance of further study on REM sleep. However, the biomarkers of REM disturbances remain unknown, leading to the lack of REM-specific neuromodulation interventions.

Objective

This study aims to investigate the neurophysiological biomarkers of REM disturbance in parkinsonian patients.

Methods

Ten PD patients implanted with bilateral subthalamic nucleus-deep brain stimulation (STN-DBS) were included in this study, of whom 4 were diagnosed with RBD. Sleep monitoring was conducted 1 month after surgery. Subthalamic local field potentials (LFP) were recorded through sensing-enabled DBS. The neurop

SUBMITTER: Guan L 

PROVIDER: S-EPMC7617463 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature