Dissemination and persistence of antimicrobial resistance (AMR) along the wastewater-river continuum.

ABSTRACT: Antimicrobial resistance (AMR) is a global health hazard. Although clinical and agricultural environments are well-established contributors to the evolution and dissemination of AMR, research on wastewater treatment works (WwTWs) has highlighted their potential role as disseminators of AMR in freshwater environments. Using metagenomic sequencing and analysis, we investigated the changes in resistomes and associated mobile genetic elements within untreated wastewater influents and treated effluents of five WwTWs, and sediments collected from corresponding river environments in Oxfordshire, UK, across three seasonal periods within a year. Our analysis demonstrated a high diversity and abundance of antimicrobial resistance genes (ARGs) in untreated wastewater influents, reflecting the varied

SUBMITTER: Read DS 

PROVIDER: S-EPMC7617467 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature