Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration.

ABSTRACT: Cell fate stability is essential to maintaining "law and order" in complex animals. However, high stability comes at the cost of reduced plasticity and, by extension, poor regenerative ability. This evolutionary trade-off has resulted in most modern animals being rather simple and regenerative or complex and non-regenerative. The mechanisms mediating cellular plasticity and allowing for regeneration remain unknown. We show that signals emitted by senescent cells can destabilize the differentiated state of neighboring somatic cells, reprogramming them into stem cells that are capable of driving whole-body regeneration in the cnidarian Hydractinia symbiolongicarpus. Pharmacological or genetic inhibition of senescence prevents reprogramming and regeneration. Conversely, induction of transient

SUBMITTER: Salinas-Saavedra M 

PROVIDER: S-EPMC7617468 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature