Dataset Information
Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis.
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ABSTRACT:
SUBMITTER: Lipworth S
PROVIDER: S-EPMC7617469 | biostudies-literature | 2024 Nov
REPOSITORIES: biostudies-literature
Publications
Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis.
The Lancet. Microbe 20241005 11
<h4>Background</h4>Antimicrobial resistance (AMR) in Escherichia coli is a global problem associated with substantial morbidity and mortality. AMR-associated genes are typically annotated based on similarity to variants in a curated reference database, with the implicit assumption that uncatalogued genetic variation within these is phenotypically unimportant. In this study, we evaluated the performance of the AMRFinder tool and, subsequently, the potential for discovering new AMR-associated gene ...[more]
